Bissinger's book, which profiled the economically depressed town of Odessa, Texas and their heroic high school football team, The Permian High Panthers.
While a source initially told the two were just friends, they were subsequently spotted spending a lot of time together.
Then came a starring role opposite in 2011's The Rum Diary, which caused Heard's profile to rise significantly when the co-stars eventually got married and later divorced in.
While the actress has been a frequent tabloid target ever since, there's still much her fans may not know about her.
Australia maintains strict quarantines over the importation of animals, and the country's agriculture minister, Barbaby Joyce, was simply not having it.
But while Depp did not face repercussions from the incident, Heard did.