At the age of 19, del Castillo became known for her lead role in the for in 1991.
And risked my life, my parents' life, my sister's life and everybody surrounding me.
She made her American debut in 2003, by appearing in American Family.
She brokered an interview between American actor and Guzmán in October 2015, shortly before recaptured him del Castillo claims in her that she did not know Penn intended to interview the drug lord during the meeting.
Her parents are Kate Trillo Graham and Eric del Castillo, a pioneer of the Mexican cinema.
The performance earned her , , and nominations, making her the first Mexican actress to be nominated for three theatre awards in New York.