I started tapping her nipple and feeling all around her giant boobs, squeezing, cupping, circling, massaging, rubbing, stretching, gently rubbing, tapping, pinching her nipple,massaging every part of her boobs, and just playing with them.
Although may do a lot of fire damage, it doesn't do a lot of damage against Big Sisters since it counts as Antipersonnel rounds.
I really love touching her, but I don't know if she wants me to or not! Big Sisters are able to withstand immense water pressure can be seen venturing outside of Rapture as the Big Daddies do.
Big Sisters are formidable beings possessing great agility and Plasmid powers.
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Since she cannot be defeated, one should try to conserve health and ammo by keeping the sculpture in the middle of the room or other objects between the Big Sister and the player.